刘北东

【 来源: 时间:2020-11-16 浏览:

姓名:刘北东

职称:教授

学科领域(科研方向):利用酵母高通量筛选平台从事细胞抗逆性及衰老机理的研究

个人简述:

刘北东,博士,以酵母为研究对象建立了大规模表型组研究系统,主要从事细胞衰老以及胁迫条件下的细胞信号通路和调节机制等方面的研究。独立主持瑞典国家自然科学基金、瑞典癌症研究基金等多项基金项目。并在高水平学术期刊发表论文20余篇(平均影响因子11.75),其中以第一作者在Cell杂志上发表论文2篇,共同作者发表1篇,以通讯作者在Science杂志上发表论文1篇。

教育背景及工作经历:

1998-2001 东北农业大学硕士

2001-2004 哈尔滨工业大学博士

2004-2005瑞典哥德堡大学博士后

2005-2006加拿大多伦多大学Charlie Boone实验室博士后

2006- 2010瑞典哥德堡大学Thomas Nyström实验室博士后

2010开始在瑞典哥德堡大学化学与分子生物学系担任研究员

2013 升任副教授,2015开始担任系里细胞高通量筛选研究中心负责人

2017年聘为浙江农林大学省部共建亚热带森林培育国家重点实验室教授。

科研项目:浙江农林大学人才启动费 100

主要论文:

1. Beidong Liu*, Lisa Larsson, Antonio Caballero, Xinxin Hao, David Oling, Julie Grantham, and Thomas Nystrom* (2010). The polarisome is required for segregation and retrograde transport of protein aggregates. Cell 140, 257-267.

2. Beidong Liu*, Lisa Larsson, Vanessa Franssens, Xinxin Hao, Sandra M. Hill, Veronica Andersson, Daniel Hoglund, Jia Song, Xiaoxue Yang, David Oling, Julie Grantham, Joris Winderickx, and Thomas Nystrom* (2011). Segregation of protein aggregates involves actin and the polarity machinery. Cell 147, 959-961.

3. Sandra Malmgren Hill, Xinxin Hao, Beidong Liu*, and Thomas Nyström* (2014). Life-span extension by a metacaspase in the yeast Saccharomyces cerevisiae. Science 344, 1389-1392.

4. Jia Song, Qian Yang, Junsheng Yang, Lisa Larsson, Xinxin Hao, Xuefeng Zhu, Sandra Malmgren-Hill, Marija Cvijovic, Julia Fernandez-Rodriguez, Julie Grantham, Claes M. Gustafsson, Beidong Liu*, and Thomas Nyström (2014). Essential Genetic Interactors of SIR2 Required for Spatial Sequestration and Asymmetrical Inheritance of Protein Aggregates. PLOS Genetics 10, e1004539.

5. Xiaoxue Yang, Yi Shen, Elena Garre, Xinxin Hao, Daniel Krumlinde, Marija Cvijović, Christina Arens, Thomas Nyström, Beidong Liu*, and Per Sunnerhagen* (2014). Stress Granule-Defective Mutants Deregulate Stress Responsive Transcripts. PLOS Genetics 10, e1004763.

6. Junsheng Yang, Xinxin Hao, Xiuling Cao, Beidong Liu*, and Thomas Nyström* (2016). Spatial sequestration and detoxification of Huntingtin by the ribosome quality control complex. eLife 5, e11792.

7. Sandra M. Hill, Xinxin Hao, Johan Gronvall, Stephanie Spikings-Nordby, Per O. Widlund, Triana Amen, Anna Jorhov, Rebecca Josefson, Daniel Kaganovich, Beidong Liu*, and Thomas Nystrom* (2016). Asymmetric Inheritance of Aggregated Proteins and Age Reset in Yeast Are Regulated by Vac17-Dependent Vacuolar Functions. Cell Rep 16, 826-838.

8. Sarah Hanzen, Katarina Vielfort, Junsheng Yang, Friederike Roger, Veronica Andersson, Sara Zamarbide-Fores, Rebecca Andersson, Lisa Malm, Gael Palais, Benoit Biteau, Beidong Liu, Michel B. Toledano, Mikael Molin* and Thomas Nystrom* (2016). Lifespan Control by Redox-Dependent Recruitment of Chaperones to Misfolded Proteins. Cell 166, 140-151.

9. Lihua Chen, and Beidong Liu* (2017). Relationships between Stress Granules, Oxidative Stress, and Neurodegenerative Diseases. Oxidative Medicine and Cellular Longevity 2017, 10.

10. Beidong Liu* (2014). The Yin and Yang of a metacaspase. Cell Cycle 13, 3471-3472.

11. Thomas Nyström*, and Beidong Liu (2014a). The mystery of aging and rejuvenation—a budding topic. Current Opinion in Microbiology 18, 61-67.

12. Thomas Nyström*, and Beidong Liu (2014b). Protein quality control in time and space – links to cellular aging. FEMS Yeast Research 14, 40-48.

13. Xuefeng Zhu, Lihua Chen, Jonas O. P. Carlsten, Qian Liu, Junsheng Yang, Beidong Liu, and Claes M. Gustafsson* (2015). Mediator tail subunits can form amyloid-like aggregates in vivo and affect stress response in yeast. Nucleic Acids Research 43, 7306-7314.

14. Ju Zheng, Junsheng Yang, Young-Jun Choe, Xinxin Hao, Xiuling Cao, Qian Zhao, Yuejie Zhang, Vanessa Franssens, F. Ulrich Hartl, Thomas Nyström, Joris Winderickx, and Beidong Liu* (2017). Role of the ribosomal quality control machinery in nucleocytoplasmic translocation of polyQ-expanded huntingtin exon-1. Biochemical and Biophysical Research Communications 493, 708-717.

15. Lisa L. Berglund, Xinxin Hao, Beidong Liu, Julie Grantham, and Thomas Nyström* (2017). Differential effects of soluble and aggregating polyQ proteins on cytotoxicity and type-1 myosin-dependent endocytosis in yeast. Scientific Reports 7, 11328.

16. Veronica Andersson, Sarah Hanzén, Beidong Liu, Mikael Molin, and Thomas Nyström* (2013). Enhancing protein disaggregation restores proteasome activity in aged cells. Aging (Albany NY) 5, 802-812.

17. Gernot Fruhmann, David Seynnaeve, Ju Zheng, Karen Ven, Sofie Molenberghs, Tobias Wilms, Beidong Liu, Joris Winderickx, and Vanessa Franssens* (2017). Yeast buddies helping to unravel the complexity of neurodegenerative disorders. Mechanisms of Ageing and Development 161, 288-305.

 联系方式:浙江农林大学智能楼S300


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